WHAT ARE THE EFFECTS OF THIS DRUG?
↑ 15.62 to 20.24 pounds in short term studies in people who had not taken antipsychotic therapy before. (220)
↑ 22.44 to 33.88 pounds in long term studies. [Systematic critical reappraisal (220)]
↑ 5.05 pounds per month [(Systematic review of 34 years of literature (4)]
↑ 16.06 pounds average in 12 weeks in a study for Psychosis (196) ↑ 61.5% of people gain > greater than 7% baseline weight in 12 weeks in a study for Psychosis (196) ↑ 9.13 pounds average in 10 weeks study for use in Psychosis and Bipolar (28)
↑ 2 pounds per month in large study of 1493 patients with schitzophrenia who had taken antipsychotic therapies previously. [Large study (2220)]
↑ 9.02 to 26.4 pounds in 6 months to 1 year study for use in Psychosis and Bipolar (28)
↑ 9.13 pounds average in 10 weeks [Meta-analysis of 81 studies (67)]
↑ 8.58 pounds average in 12 weeks in study for Bipolar (160) ↑ 5.28 lbs. Meta-analysis over varying times (700)
↑ 15.62 pounds average in 12 weeks in study for Psychosis (196)
↑ 11.88 pounds average in 14 weeks in study for Schizo-affective disorder (162)
↑ 6.16 pounds average in 24 weeks in study for borderline personality disorder (163)
↑ 8.14 pounds average in 12 weeks in study for personality disorder (166) ↑ 6.16 pounds average in 24 weeks in study for Acute mania (155) ↑ 9.46 pounds average in 12 weeks in study for Alcohol dependence (165)
↑ 9.24 lbs. avg. in 26 weeks for Schizophrenia (167) ↑ 8.58 lbs. avg. in 26 weeks in study for Schizophrenia (168)
↑ 8.6 to 35.64 pounds in youths taking olanzapine (Zyprexa) (n=353 youth) (725)
↑ 55% people gained↑ 7 % or > greater weight in first 6 weeks of therapy if Quetiapine was the 1st antipsychotic medication taken (p 0.009) in study of varied diagnoses [Meta-analysis of 307 studies (56)]
↑ 41% of people taking Olanzapine gained 7% or more of their baseline weight in greater than > 38 weeks p<0.001. [Meta-analysis of 307 studies (56)]
↑ NNH (Number Needed to Harm) for 7% weight gain in Youth with Psychotic and Bipolar Disorders is 3 young people taking olanzapine (Zyprexa) (725)
↑ If 3 Youth take Olanzapine at least one will experience greater than 7% weight gain. (725)
↑ “Antipsychotic-related weight gain and metabolic adverse effects have become a major focus, especially in youth. Results of 34 head-to-head and placebo controlled trials (725)
↑ Antipsychotic polypharmacy (taking 2 or more antipsychotic drugs together) increased the risk for obesity by 2.28X (2.28 times) in children and adolescents. (725)
↑ Antipsychotic polypharmacy (taking 2 or more antipsychotic drugs together) increased the risk for any heart disease event, cerebrovascualar event (like stroke), or high blood pressure adverse events by 1.72X greater risk (1.72 times increased risk) in children and adolescents. (725)
↑ “However, despite marked weight gain and its greater impact on youth, monitoring rates are low and studies of pharmacologic and behavioral interventions are extremely limited.” Results of 34 head-to-head and placebo controlled trials (725) ↑ 55% people gain ↑ 7% or greater weight in less than 6 weeks if is 1st antipsychotic drug taken p<0.009 study with varied diagnoses [Meta-analysis of 307 studies (56)]
↑ 72% of people taking 2nd generation antipsychotics gained 7% or more of their baseline weight in greater than > 38 weeks p<0.001 [Meta-analysis of 307 studies (56)]
↑ Virtually all antipsychotic medications are associated weight gain over time. [Meta-analysis of 307 studies (56)] and [Meta-analysis of 81 studies (67)] and (2200, 2190, 2208)
↑ Both 1st and 2nd generation antipsychotics are associated with weight gain. [Meta-analysis of 81 studies (67)
Generic Name: Olanzapine