WHAT ARE THE EFFECTS OF THIS DRUG?
↑ 8.8 to 12.32 pounds in short term studies of people who had not taken antipsychotic therapy before. (220)
↑ 14.52 to 19.58 pounds in long term studies. [Systematic critical reappraisal (220)]
↑ 4.62 pounds average in 24 weeks for Schizophrenia (169)
↑ 3.3 pounds average in 6 weeks for Schizophrenia (198, 199)
↑ 2.2 pounds weight gain per month. [(Systematic review of 34 years of literature (4)]
↑ 28 % of people gain ↑ 7 % or more of their baseline weight in > greater than 38 weeks p<0.001 study of varied diagnoses (56)
↑ 5.06 pounds average in 14 weeks for Schizo-affective disorder (162)
↑ 38% people gained ↑ 7 % or > greater weight in first 6 weeks of therapy if Risperidone was the 1st antipsychotic medication taken (p 0.009) in study of varied diagnoses [Meta-analysis of 307 studies (56)]
↑ 55% people gained↑ 7 % or > greater weight in greater than > 38 weeks of therapy if Risperidone was the 1st antipsychotic medication taken (p 0.008) in study of varied diagnoses [Meta-analysis of 307 studies (56)]
↑ 4.62 pounds average in 10 weeks [Meta-analysis of 81 studies (67)] and (28)
↑ 1.76 pounds average vs placebo (no drug) (time not specified) in Meta-analysis study (700)
↑ 4.18 to 15.84 pounds in youths taking risperidone (Risperdal) (n=571 youth) (725)
↑ NNH (Number Needed to Harm) for 7% weight gain in Youth with Psychotic and Bipolar Disorders is 6 young people taking risperidone (Risperdal) (Results of 34 head-to-head and placebo controlled trials 725)
↑ If 6 Youth take Risperidone at least one will experience greater than 7% weight gain. (725)
↑ “Antipsychotic-related weight gain and metabolic adverse effects have become a major focus, especially in youth. Results of 34 head-to-head and placebo controlled trials (725)
↑ Antipsychotic polypharmacy (taking 2 or more antipsychotic drugs together) increased the risk for obesity by 2.28X (2.28 times) in children and adolescents. (725)
↑ Antipsychotic polypharmacy (taking 2 or more antipsychotic drugs together) increased the risk for any heart disease event, cerebrovascualar event (like stroke), or high blood pressure adverse events by 1.72X greater risk (1.72 times increased risk) in children and adolescents. (725)
↑ “However, despite marked weight gain and its greater impact on youth, monitoring rates are low and studies of pharmacologic and behavioral interventions are extremely limited.” Results of 34 head-to-head and placebo controlled trials (725)
↑ 72% of people taking 2nd generation antipsychotics gained 7% or more of their baseline weight in greater than > 38 weeks p<0.001 [Meta-analysis of 307 studies (56)]
↑ Virtually all antipsychotic medications are associated weight gain over time. [Meta-analysis of 307 studies (56)] and [Meta-analysis of 81 studies (67)] and (2200, 2190, 2208)
↑ Both 1st and 2nd generation antipsychotics are associated with weight gain. [Meta-analysis of 81 studies (67)]
Generic Name: Risperidone