WHAT ARE THE EFFECTS OF THIS DRUG?
↑ 1.98 to 5.72 pounds in 16 to 26 weeks (25)
↑ 4.18 to 6.16 pounds over 52 weeks dose of < less than or = 45 mg per day (182)
↑ Weight gain is fat and water (25 and 27)
↑ 5.72 pounds in 16-26 weeks for dose 45 mg/day when given alone for diabetes (25)
↑ 3.3 pounds average in 52 weeks for doses less than or = 45 mg / day (184)
↑ When added to insulin weight gain more dramatic than expected for combo (27)
↑ 3.96 pounds average in 24 weeks for dose of 45 mg/day in combo with metformin (25)
↑ 9.02 pounds average in 24 weeks with dose of 45 mg/day in combo with sulfonylurea (25)
↑ 9.02 pounds average in 24 weeks for dose of 45 mg/day in combo with insulin (25,27)
↑ 5.72 pounds average vs placebo (no drug) time not specified in Meta-analysis study (700)
* FDA Alert: Thiazolidinediones, including pioglitazone, can cause or exacerbate congestive heart failure (CHF) in some patients.
* FDA Warning: FDA has concluded that pioglitazone (Actos, Actoplus Met, Actoplus Met XR, Duetact, Oseni) may be linked to an increased risk of bladder cancer.
Generic Name: Pioglitazone