Glyxambi (Discontinued) CA

WHAT ARE THE EFFECTS OF THIS DRUG?
Linagliptin not associated with weight gain when taken with metformin (587)
Linagliptin did not promote weight gain if taken with metformin (587)
↓ Weight 5.3-5.5 pounds at 52 weeks (577) loss may plateau at 26-34 weeks when Empagliflozin is given alone (568)
* FDA Warnings for Empagliflozin (and (SGLT2) Inhibitors):
↑ Ketoacidosis risk (difficulty breathing, vomiting, abdominal pain, confusion, sleepiness)
↑ risks of serious UTI (urinary tract infections)
↑ bone fractures
* FDA Warning Aug 2015 Linagliptin (and DPP-4 Inhibitors) for diabetes may cause severe joint pain and all diabetes drugs in this subfamily of diabetes drugs but Sitagliptin (Januvia) may cause heart failure
↑ Weight if Linagliptin is taken with pioglitizone (797)
Generic Name: Empagliflozin &
Linagliptin

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