WHAT ARE THE EFFECTS OF THIS DRUG?
↑ 2.57 pounds average per month (18)
↑ 11 to 25% of people gained > greater than 7 % weight if taken for 6 to 8 weeks (4)
↑ 25% people gained ↑ 7 % or > greater weight in > 38 weeks if Quetiapine was the 1st antipsychotic medication taken p<0.001 in study of varied diagnoses [Meta-analysis of 307 studies (56)]
↑ 19 % of people gained ↑ 7% or more of their baseline weight in greater than > 38 weeks p<0.001 study with varied diagnoses [Meta-analysis of 307 studies (56)]
↑ 2.42 pounds average vs placebo (no drug) (time not specified) in Meta-analysis study (700)
↑ 3.96 pounds weight gain per month. [(Systematic review of 34 years of literature (4)]
↑ 5.06 to 13.42 pounds in youths taking quetiapine (Zyprexa) (n=133 youth) (725)
↑ NNH (Number Needed to Harm) for 7% weight Gain in Youth with Psychotic and Bipolar Disorders is 9 young people taking quetiapine (Zyprexa) (725)
↑ If 9 Youth take Aripiprazole at least one will experience greater than 7% weight gain. (725)
↑ “Antipsychotic-related weight gain and metabolic adverse effects have become a major focus, especially in youth. Results of 34 head-to-head and placebo controlled trials (725)
↑ Antipsychotic polypharmacy (taking 2 or more antipsychotic drugs together) increased the risk for obesity by 2.28X (2.28 times) in children and adolescents. (725)
↑ Antipsychotic polypharmacy (taking 2 or more antipsychotic drugs together) increased the risk for any heart disease event, cerebrovascualar event (like stroke), or high blood pressure adverse events by 1.72X greater risk (1.72 times increased risk) in children and adolescents. (725)
↑ “However, despite marked weight gain and its greater impact on youth, monitoring rates are low and studies of pharmacologic and behavioral interventions are extremely limited.” Results of 34 head-to-head and placebo controlled trials (725)
↑ 72% of people taking 2nd generation antipsychotics gained 7% or more of their baseline weight in greater than > 38 weeks p<0.001 [Meta-analysis of 307 studies (56)]
↑ Virtually all antipsychotic medications are associated weight gain over time. [Meta-analysis of 307 studies (56)] and [Meta-analysis of 81 studies (67)] and (2200, 2190, 2208)
↑ Both 1st and 2nd generation antipsychotics are associated with weight gain. [Meta-analysis of 81 studies (67)]
Generic Name: Quetiapine