WHAT ARE THE EFFECTS OF THIS DRUG?
↑ 1.54 pounds average in 4-6 weeks for 10 mg/day dose in schizophrenia or schizoaffective disorder (199)
↑ 2.64 pounds average in 4-6 weeks for 20mg/day dose in schizophrenia or schizoaffective disorder (199)
↑ 1.1 pounds avg. in 4-6 weeks for 30mg/day dose, in 4 weeks in schizophrenia or schizoaffective disorder (199)
↑ 26% of people taking Aripiprazole gained 7% or more of their baseline weight in greater than > 38 weeks p<0.001 if Aripiprazole was the first antipsychotic medication they took. [Meta-analysis of 307 studies (56)]
↑ 21% of people who took Aripiprazole gained 7% or more of their baseline weight in greater than > 38 weeks p<0.001. [Meta-analysis of 307 studies (56)]
↑ NNH (Number Needed to Harm) for 7% weight gain is 20 adults taking Aripiprazole (1557, 1560)
↑ If 20 Adults take Aripiprazole at least one will experience greater than 7% weight gain. (1557, 1560)
↑ NNH (Number Needed to Harm) for 7% weight Gain in Youth with Psychotic and Bipolar Disorders is 39 young people taking aripiprazole (Abilify) (725)
↑ If 39 Youth take Aripiprazole at least one will experience greater than 7% weight gain. (725)
↑ 0 to 9.68 pounds in youths taking aripiprazole (Abilify) (n=451 youth). (725)
↑ “Antipsychotic-related weight gain and metabolic adverse effects have become a major focus, especially in youth. Results of 34 head-to-head and placebo controlled trials (725)
↑ Antipsychotic polypharmacy (taking 2 or more antipsychotic drugs together) increased the risk for obesity by 2.28X (2.28 times) in children and adolescents. (725)
↑ Antipsychotic polypharmacy (taking 2 or more antipsychotic drugs together) increased the risk for any heart disease event, cerebrovascualar event (like stroke), or high blood pressure adverse events by 1.72X greater risk (1.72 times increased risk) in children and adolescents. (725)
↑ “However, despite marked weight gain and its greater impact on youth, monitoring rates are low and studies of pharmacologic and behavioral interventions are extremely limited.” Results of 34 head-to-head and placebo controlled trials (725)
↑ 72% of people taking 2nd generation antipsychotics gain 7% or more of their baseline weight in greater than > 38 weeks p<0.001 [Meta-analysis of 307 studies (56)]
↑ Virtually all antipsychotic medications are associated weight gained over time. [Meta-analysis of 307 studies (56)] and [Meta-analysis of 81 studies (67)] and (2200, 2190, 2208)
↑ Both 1st and 2nd generation antipsychotics are associated with weight gain. [Meta-analysis of 81 studies (67)]
Generic Name: Aripiprazole