WHAT ARE THE EFFECTS OF THIS DRUG?
↑ 9.79 pounds average in 10 wks [Meta-analysis of 81 studies (67)] and (28)
↑ 11.66 to 16.94 pounds in 6 months - 1 year (30)
↑ 9.24 pounds average in 14 weeks (162)
↑ 3.74 pounds per month. [(Systematic review of 34 years of literature (4)]
↑ 21.78 pounds average in 52 months (159)
↑ 48% of people taking Clozapine gained 7% or more of their baseline weight in greater than > 38 weeks p<0.001. [Meta-analysis of 307 studies (56)]
↑ 1.98 to 20.9 pounds in youths taking clozapine (Clozaril) (n=97 youth) (725)
↑ “Antipsychotic-related weight gain and metabolic adverse effects have become a major focus, especially in youth. Results of 34 head-to-head and placebo controlled trials (725)
↑ Antipsychotic polypharmacy (taking 2 or more antipsychotic drugs together) increased the risk for obesity by 2.28X (2.28 times) in children and adolescents. Results of 34 head-to-head and placebo controlled trials (725)
↑ Antipsychotic polypharmacy (taking 2 or more antipsychotic drugs together) increased the risk for any heart disease event, cerebrovascualar event (like stroke), or high blood pressure adverse events by 1.72X greater risk (1.72 times increased risk) children and adolescents. Results of 34 head-to-head & placebo controlled trials (725)
↑ “However, despite marked weight gain and its greater impact on youth, monitoring rates are low and studies of pharmacologic and behavioral interventions are extremely limited.” Results of 34 controlled trials. (725)
↑ 72% of people taking 2nd generation antipsychotics gained 7% or more of their baseline weight in greater than > 38 weeks p<0.001 [Meta-analysis of 307 studies (56)]
↑ Virtually all antipsychotic medications are associated weight gain over time. [Meta-analysis of 307 studies (56)] and [Meta-analysis of 81 studies (67)] and (2200, 2190, 2208)
↑ Both 1st and 2nd generation antipsychotics are associated with weight gain. [Meta-analysis of 81 studies (67)]
Generic Name: Clozapine